NEET ANTI HIV DRUGS

yeah hi everyone I think it's after a long time that I'm taking a video for you uh so uh because of the request from you guys okay coming to the pharmacology pharmacology is one of the toughest part as everyone things as I even I agree for this pharmacology is one of the toughest one and it is completely memory based so not only pharmacology there are many subjects which are completely memorized in fact complete 240 marks examination of neat is going to be completely memorable it's not logical way what we think in or physics or chemistry or mathematics where you can sit and come out with a formula and you can come out with an answer it's not like that it's not a concept oriented and few questions very few questions or concept or smart smart way of answering like apart from the 40 odd questions where you need to go for the elimination based method rest all questions or in fact every question is a memory based question so uh from the past 10 days we are going with lots of basic stuffs and I mean everyday we are having few sorts of good revisions good good classes and it's all like making the stuff very simplified means subjecting them to easy to eat like easy to understand the things so it's all like whatever the basic things the you have to be perfect with the synopsis first of all you need to have a proper synopsis where you need to organize each and everything and then you need to read them then you need to solve problem mcqs then you need to uh go through the synopsis again interact with each other so this is how you need to go with the basics right so apart from the decent result what we have made in the recent neat examination with 44 gdcs out of which 17 gdcs are from Andra and Telangana and rest from all India and state counselings so that's a great achievement because last last year we have only 21 gdcs and uh the team uh with the students with the last last year students we made a we made a move like at least by next year we need to enter and we need to make gdcs so it's a very good result that 30 is our Target but we made 44 it's very decent enough so we keep a target for this year that is 60 gdcs conquers we need to make 60 gdcs this year at any cost and the team is ready for that for you guys to work day and night and this 6 months you need to make it very hard you need to work hard in hell and we need to end up with at least 6 CG that's the target okay so going into the today's class that is the anti anti HIV drugs or anti- retroviral drugs or a part of viral therapy so I just want to give this brief introduction that is how this HIV is going to affect the individual and how the process and the drugs of the classification of the category of these Antro retroviral drugs where does they act and everything so once the HIV is there this is the HIV cell and this is the commonly infected CD4 or the helper cells this is a CD4 or helper cells like with this code protein that is gp41 uh the HIV cell is going to enter the CD4 and the CD4 they will have receptors these are the receptor that is ccr5 and cxcr4 these are the receptors which are ass out of these this five receptor is the main receptor it is the main one uh which is responsible okay so once it enters it's the viral RNA is going to convert it into viral DNA by a simple enzyme well-known enzyme that is reverse transcript as enzy and once the viral DNA is going to be integrated with human DNA this is called as an integr is the enine that is used and finally an RNA is formed a combination of DNA and a viral DNA the RNA I mean the DNA is formed which is again going to converted into RNA the RNA is going to give you the proteins which are initially inactivated and this process is called as an translation and the proteases are going to act to active these proteins that is the inactive protein is going to be converted into active protein and this active protein will goes out and again it's going to infect the new CD4 cells so at each step there is a particular drug acting and inhibiting this process one here one here one here and one here right so this is a basic stuff or the basic logical whatever like you feel like it if it is a concept thing uh just related to your Concepts so and next moving to the basic classification okay uh in this basic classification it's very easy coded classification where you need to remember uh there are many vids in this classification actually but you need to remember the three for now we'll remember just two that is one here and one here means you need to remember these two drugs for now okay so please try to practice once or twice we'll go further into the classification so first is uh nucleoside reverse transcript is in Inhibitors uh okay uh what are they nucleos transcript as Inhibitors you can remember you can solve once the classification is done for now you remember because it is nucleoside right all are not nucleoside there is one exception that is a nucleotide this is nucleotide where you can remember it is very easy uh very easy one t t t okay it is very easy okay all of these are nucleus side except one that is related to T that is nucleotide simple done we are done with the first category so we are going to the second category second category you can remember with the word Den d e n done so second category is with the word den and third category is protas Inhibitors and you can remember with the word n a v i r all protes will have n a v i r 1 1 2 3 4 5 6 7 and after this class I feel like the most easiest question is identify which of the following is a proteas inhibitor right simple because you will have an V in it and you can identify easily without knowing anything so the next categories are these three categories I was talking about you have to remember two WS right uh one in the first category and third we is this okay uh these are most commonly asked questions okay entry inhibitor you can break this entry inhibitor okay uh en en means envelope the envelope is nothing but what we have discussed because HIV has a protein which helps in entering into the CD4 count with this uh The receptors that are available on the CD4 that is gp41 that is the envelop and inhibits the I mean the fusion F fu is called as a fusion and it's going to play with the T Cell so you can remember this this is the most one of the most commonly asked question and coming to the last category because I I'm I have previously told that CCR is the main one right main receptor that is responsible and you can remember this m m done you're done with that and integrat inhibitor uh if you go like uh you'll have TR we'll have TR that is the integr inhibitor right so this is a simple way of of uh going with the classification of anti HIV so I mean uh I have seen many questions related to these particular drugs there are three or four drugs most of the questions are related to this uh this is the most commonly used drug in the case of HIV and whenever there is a needle stick injury uh for the patient as well as for the doctor the immediate prophylaxis should be done with this drug or whenever there is a chances of vertical transmission of HIV from the mother to Fus you can advise this drug but the major side effect of this drug is bone marrow suppression and this drug is contraindicated whenever the patient is having less HP anemic patient because there is a bone marrow suppression so that that is the key question I have seen this key question in the recent neat examination so one more add-on point is like refampin is going to increase the clearance rate of this particular drug and with this drug there are few uh adverse effects like lipo drro fix syndrome nail hyperpigmentation and lipop so there is a few side effects coming to the next most commonly asked question the most commonly asked question is a dose limiting pancreatits okay so the bio availability please just go through the rest of the points so this is one of the most commonly asked question and there is an indirect question related to this question in the recent need examination so this is the third category this is also related to the dose limiting but it's related to the peripheral neuropathy and it causes lactic acior is because it's going to affect the mitochondrial toxicity so indirectly it's going to cause or decrease the ph and increase the H+ ion levels and it also results in the ban but the most important point is like lipo distrophy is among all the antiviral drugs this is the one which is having the best lipodystrophic syndrome okay yeah done for now so I feel like this uh video is useful uh to come out with new pneumonics and Cotes and make this uh classification very simple and easy uh guys uh this classification is very very important because uh I have seen many many questions related to this classification in these recent examinations okay so recent examinations they're very concerned about this classification because HIV is very very related to the dentist right it is related to the dentist so so it is must you have to go through this classification okay and uh definitely we are going to come up with few more videos very soon please try to uh follow the group give your best and please try to work please try to spend as much as time as possible with the group in this span of 6 months you have left over with 6 months and your target is to be done okay so thank you all the best and take care