Clotting mechanism & Anticoagulants

hi Venus this is dr. Steven from Team MDS conquer now I'm here with the topic trotting mechanism okay first of all the most important thing is you need to write down the definition of clotting or coagulation okay so plotting or correlation can be defined as a process in which the blood loses it fluidity and become a jelly-like mass within few minutes after it is shut out or collected in a container so you need to go ahead with the definition so once you're done with the definition you need to write about the clotting factors and I hope you remember the common code of the mnemonic that we used to follow in the lemon standard that is foolish people try climbing long slopes after customers common some people have fun okay so that is the core in which I hope you remember that sixth factor is missing okay so code is foolish which is F next one is people and it is the pee try 40 Clym b4c log for our slopes for us after Andy customers against some people P have H fallen F so this is the court if you remember this code and you can restore this beautiful table which is very very important so once you are done with this you need to write about the stages of clotting which includes three stages that is the formation of thrombo prothrombin activator and conversion of prothrombin to thrombin and conversion of fibrinogen to fibrin which is clearly given this is the step 1 okay that is prothrombin activator the step 2 conversion of proteome into thrombin step 3 formation of fibrin from fibrinogen okay so you need to give a brief idea about this that is the first step which is the Protomen activator is divided into two things okay one is intrinsic factor and extrinsic factor and all these series of reactions are very very important I am going to give it very simple logical code which you can return for a longer duration of time about the intrinsic and extrinsic factors okay so all these tables has to be the flowcharts has to be clearly given so that the paper settle the paper evaluator will get a clear-cut idea that you are very strong in this particular subject okay next important thing how to remember the factors it's very simple you can write it as the intrinsic and the extrinsic okay so the intrinsic and the extrinsic right so you can keep an X in the center X means 10 so the left our factors from the tennis it starts from 12 12 is going to activate 11 10 is already there so 11 is going to activate 9:00 okay 9:00 is going to activate 8 and 8 is activate them clear so which factor is left over here seven is left or so seven is going to be the part in the extensive bathroom okay so we are done with we are done with ten which is the main one activated both in the extrinsic as well as the instant intrinsic pathways so we are done with eleven we are done with wall we are done with nine we are done with eight and we are done with seven and you know that six is absent so the leftover are five okay four four is calcium and two one okay so four two one other leftover is right so by which this is a common pathway and this is the extrinsic this is the extrinsic pathway and this is sorry this is the intrinsic pathway and this is the extrinsic pathway by which he can easily write down the sequence of activations of each clotting factor and the enzymes or the substrate that are involved in this so this is all about the basic clotting methods and some application aspects like which one whenever there is a drop in this particular clotting factor you can do this or extrinsic pathway is related to which times like if it I take about the blood picture you'll have bleeding time clotting time for throwing time activated protein time so there are many such times which is going to activate at which level if you mention a table as an application plant that is more than sufficient hemophilia is due to deficiency of B is due to deficiency of one Billy one factor all these extra applications things that you have to add of the power basing upon the time that is available forever so once you are done with this okay it's the second important question which is related to this or which you can write as an application partes anticoagulants okay so anticoagulant mechanism of the blood can be divided into two factors that is the physical factors and chemical factors the notes for this physical and chemical I'm going to provide you on the group in the form of a PDF so the next one is you need to write briefly about the anticoagulants Aquarians can be used to prevent the blood clotting inside the body in vivo and which prevents the blood clotting that is collected from the body in vitro or can be from both in value as well as in brittle these are the three things and this is taken directly from clay III part and you need to mention this classification that is what is parental what are given oral because again oral anticoagulants can be another question I have seen this question most commonly in end up in the papers related to endo basics surgery basics and pareo basis okay mostly these three people the handle more blood and it's most commonly asked question for the oral surgery department okay so you need to write about this classification in be line in detail that is in direct thrombin inhibitors direct raman inhibitors okay so this is this is very very important okay direct factor Xa inhibitor or related thrombin inhibitors all these are important okay so in this few things few few few aspects we need to go in-depth basing upon the length of the question I feel this question cannot be given for a twenty marks maybe along with the clotting mechanism and anticoagulants can be given for twenty months as an application based question specifically for oral surgery department people but for most of other departments it will be an individual question which cannot be for 20 months so as it is not for 20 marks you cannot describe each and everything so you you can elaborate few things like your her parents are most commonly used right so you can write some some important aspects about her parent or some important aspects about over firing because they are most commonly asked or you can talk about the C traits and all this okay so that is important so before coding the article what are the subheadings for example if you are talking about heparin or if you are talking about any other any other particulars it rates or you can talk about EDTA EDD is again used as anticoagulant right so or you can talk about , and elevators so any of this make sure you try to keep at least like to hitting some basic introduction some basic introduction introduction of the particular is it followed by the mechanism of action or you can write about pharmacokinetics brief pharmacokinetics or pharmacodynamics forward by the uses uses of the particular turk uses or uses of the particular drug and the dose all these headings are going to give more good impression basically good impression and more school-age senses from the person who is correcting your pepper so once you are done with all the source those things because as this question is most commonly asked for the surgery and end of people I have coded two references like before going to conclusion you need to code such application based questions you need to code at least two subject related references or a small studies over them like how we 70 coagulants useful how authentic events affect - are there any recent articles something like if you are a barrier person try to correct to parry or related and or 90 coagulants before if you don't find pareo related go for general dentistry no problem you can go for general dentists like dental management of a patient receiving anticoagulants this is this is something related to general dentistry right correct you can code for oral surgery also right oral surgery you can quote this for Perry also so basing upon the question you can code a relevant departmental related code that is mandatory so this is is taken from journal Journal of all sciences we hard code everything and you please write down and write some conclusion related to this okay and similarly is is the stopping of antipodal interfere really requiring minor dental surgery okay however in pedantic micro surgery okay I mean this particular article will have some basic conclusion so write those things in the conclusion and try to code these articles which definitely give some concepts definitely give a sound confidence for the person who is correcting your paper so that he will definitely add extra scores for you so once you're done with this I always said before going for conclusion as a heading okay you can keep the codings I mean the previously I have discussed this you can keep this as evidence based dentistry I was talking about evidence based so you can keep evidence-based dentistry heading followed by you can quote two articles related to your particular department and followed by the general references like general references one I have quoted for KT three party that is particularly oral anticoagulants related classification and the second one all the physiology must guide and gano and your symbol in common okay so you can quote this apart from these four you can quote two articles I told like two department based references okay two department based references so totally six are more than sufficient if it is the twenty marks question if it is a if it is a like ten marks or seven marks I feel like three are more than like you can go for any of these two followed by one departmental based difference or basing upon the time available because finishing is always important right in the dentistry finishing is always important and I feel like finishing will be mostly by the conclusion or the evidence base reference heading to and your references so this finishing is going to give you the extra scores so I'm done with this particular topic okay thank you all signing off dr. shreek on from team MDS quarter